Streptococcus pneumoniae

Antibiotic
% Susceptible
 
Antibiotic
% Susceptible
Ampicillin
+
   Imipenem
+
Azithromycin
85
   Levofloxacin
99
Aztreonam
-
   Meropenem
+
Cefazolin
+
   Moxifloxacin
+
Cefepime
+
   Nitrofurantoin
&
Ceftazidime
+/-
   Oxacillin/Naf
+
Ceftriaxone
89
   Penicillin
84
Cefuroxime
+
   Piperacillin
+
Ciprofloxacin
+/-
   Piperacillin/tazo
+
Clarithromycin
60
   Ticarcillin/Clav
+
Clindamycin
80
   Tobramycin
-
Doxycycline
81
   TMP/SMX
76
Erythromycin
61
   Unasyn/Aug
100
Gentamicin
-
   Vancomycin
100
 
   

Comments:   Susceptibility breakpoints differ for meningeal vs non-meningeal pneumococcal isolates. Check with your micro lab.

 

Numeric data represent local susceptibility data.
(+) = usually effective or >60% susceptible; (+/-) = clinical trials lacking or 30-60% susceptible; (-) = not effective clinically or <30% susceptible - Adapted with permission from The Sanford Guide to Antimicrobial Therapy 2007
(*) Local (non-Sanford Guide) opinion
(S) = synergistic with penicillin/ampicillin;
(&) nitrofurantoin only useful for lower tract urinary tract infections